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It is common knowledge that Laos, Vietnam and Cambodia are the epicenter for illegal wildlife trade in Southeast Asia, where a vast variety of lucrative wildlife including bats are clandestinely shipped to wet markets of China. That said, this is certainly not the only avenue of viral dissemination by bats human capture of bats for food, and hematophagous arthropods, via mechanical transmission, may also play important roles in CoVs viral propagation in and around bats. Bats are the only group of mammals capable of sustained flight, which allows them to disseminate the viruses they harbor and enhance the chance of interspecies transmission (Wong et al. Given the numbers of alphaCoVs and betaCoVs already found in a plethora of bats species, it is obvious that these viruses have found a suitable host reservoir in Chiroptera. As a result of their unique mechanism of viral replication, CoVs have a high frequency of recombination and mutation rates, which allows them to rapidly adapt to new hosts and ecological niches (Graham et al., J. However, in the past 15 years bats have been found to be hosts to >30 CoVs with complete genome sequences (Wong et al., Viruses 2019 11,174). As their words went to press, their prediction materialized in a wet market in Wuhan, China where bats, and other species of wildlife were for sale in anticipation for the up-coming Year of the Rat Spring Festival.Д«efore the original SARS epidemic (SARS-CoV-1), bats were not known to be hosts to coronaviruses (CoVs). In their article on the Global Epidemiology of Bat Coronaviruses, Wong and colleagues ( Viruses 2019 11,174) made a strikingly predicted the emergence of SARS-CoV-2! They wrote in their article, вЂњthe presence of live bats in wildlife wet markets and restaurants in Southern China, are important for interspecies transmission of CoVs and may lead to devastating global outbreaksвЂќ. In addition to Public Health diagnostic work on suspected COVID-19 cases, Institut Pasteur du Laos is also working on: Tracking the origin and transmission/spillover of the new coronavirus SARS-CoV-2 RESEARCH ON SARS-CoV-2 AT INSTITUT PASTEUR DU LAOS Institut Pasteur du Laos is supported by a donation from governments of various countries: France, Luxembourg, USA, Japan, Canada and also individuals via direct donations or donations to the Fondation Institut Pasteur du Laos under the auspices of the Fondation de France.

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Patients sample testing is done free of charge. Positive and negative results are reported to the Lao Ministry of Health вЂ“ International Heath Regulations contact person who then relays the result to the clinician/patient and to the World Health Organization.Д®ach test has a relatively high cost of $15 US dollars and the equipment for sample preparation and analyses is also expensive. The testing of suspected case samples takes around 4 hours in order to extract the SARS-CoV-2 nucleic acids and to amplify the viral genomic material using Real-Time PCR. INSTITUT PASTEUR DU LAOS VIROLOGY TEAM WORKING BSе…ѓ-PLUS LABORATORY PREPARING COVID-19 SAMPLE FOR TESTING Samples are received from the hospital network arrive at IPL and are analyzed under adequate biosafety / biosecurity conditions within the Institut Pasteur Laos BSL-Plus laboratory the highest biosafety level laboratory in Laos. MAP of COVID-19 HOSPITAL SURVEILLANCE NETWORK FOR INSTITUT PASTEUR DU LAOS Phongsaly, Oudomxay, Vang Vieng (Vientiane Province), Xeingkhuang, Luangprabang, Savannakhet, Champassak Institut Pasteur du Laos has been assigned by the Lao MOH a surveillance network of 10 hospitals from North to South for COVID-19 detection: The Institut Pasteur du Laos has been solicited by the Lao Ministry of Health (MOH) as a front-line laboratory for COVID-19 diagnostics using RT-PCR as the method of detection. EMERGENCY PUBLIC HEALTH EFFORTS OF INSTITUT PASTEUR DU LAOS FOR COVID-19 DIAGNOSTICSДue to an unprecedented workload with numerous samples arriving at Institut Pasteur du Laos and the various public health duties, the Administration and Virology team have not been able to answer numerous requests for interviews and journalistic solicitations as we need to prioritize the urgent public health mission.

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